Mann, ZF;
Gálvez, H;
Pedreno, D;
Chen, Z;
Chrysostomou, E;
Żak, M;
Kang, M;
... Daudet, N; + view all
(2017)
Shaping of inner ear sensory organs through antagonistic interactions between Notch signalling and Lmx1a.
eLife
, 6
, Article e33323. 10.7554/eLife.33323.
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Abstract
The mechanisms of formation of the distinct sensory organs of the inner ear and the non-sensory domains that separate them are still unclear. Here, we show that several sensory patches arise by progressive segregation from a common prosensory domain in the embryonic chicken and mouse otocyst. This process is regulated by mutually antagonistic signals: Notch signalling and Lmx1a. Notch-mediated lateral induction promotes prosensory fate. Some of the early Notch-active cells, however, are normally diverted from this fate and increasing lateral induction produces misshapen or fused sensory organs in the chick. Conversely Lmx1a (or cLmx1b in the chick) allows sensory organ segregation by antagonizing lateral induction and promoting commitment to the non-sensory fate. Our findings highlight the dynamic nature of sensory patch formation and the labile character of the sensory-competent progenitors, which could have facilitated the emergence of new inner ear organs and their functional diversification in the course of evolution.
| Type: | Article |
|---|---|
| Title: | Shaping of inner ear sensory organs through antagonistic interactions between Notch signalling and Lmx1a. |
| Location: | England |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.7554/eLife.33323 |
| Publisher version: | https://doi.org/10.7554/eLife.33323 |
| Language: | English |
| Additional information: | © 2017, Mann et al. This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited. |
| Keywords: | Lmx1a, chicken, compartment boundaries, development, developmental biology, inner ear, lateral induction, mouse, notch, stem cells |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > The Ear Institute |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10040358 |
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