Burugapalli, K;
Wijesuriya, S;
Wang, N;
Song, W;
(2017)
Biomimetic Electrospun Coatings Increase the In Vivo Sensitivity of Implantable Glucose Biosensors.
Journal of Biomedical Materials Research Part A
10.1002/jbm.a.36308.
(In press).
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Abstract
In vivo tissue responses and functional efficacy of electrospun membranes based on polyurethane (PU) and gelatin (GE) as biomimetic coatings for implantable glucose biosensors was investigated in a rat subcutaneous implantation model. Three electrospun membranes with optimized fiber diameters, pore sizes, and permeability, both single PU and coaxial PU-GE fibers and a solvent cast PU film were implanted in rats to evaluate tissue responses. For functional efficacy testing, four sensor variants coated with the above mentioned electrospun membranes as mass-transport limiting and outermost biomimetic coatings were implanted in rats. The electrospun PU membranes had micron sized pores that were not permeable to host cells when implanted in the body. However, PU-GE coaxial fiber membranes, having similar sized pores, were infiltrated with fibroblasts that deposited collagen in the membrane's pores. Such tissue response prevented the formation of dense fibrous capsule around the sensor coated with the PU-GE coaxial fiber membranes, which helped improve the in vivo sensitivity for at least 3 weeks compared to the traditional sensors in rat subcutaneous tissue. Furthermore, the better in vitro sensor's sensitivity due to electrospun PU as the mass-transport limiting membrane translated to better in vivo sensitivity. Thus, this study showed that electrospun membranes can play an important role in realizing long in vivo sensing lifetime of implantable glucose biosensors.
| Type: | Article |
|---|---|
| Title: | Biomimetic Electrospun Coatings Increase the In Vivo Sensitivity of Implantable Glucose Biosensors |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1002/jbm.a.36308 |
| Publisher version: | https://doi.org/10.1002/jbm.a.36308 |
| Language: | English |
| Additional information: | This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
| Keywords: | Continuous glucose monitoring, electrospun coaxial fiber membranes, implantable electrochemical sensor, in vivo functional efficacy, tissue reactions |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci > Department of Surgical Biotechnology |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10040600 |
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