Guo, J;
Rahme, K;
He, Y;
Li, L-L;
Holmes, JD;
O'Driscoll, CM;
(2017)
Gold nanoparticles enlighten the future of cancer theranostics.
International Journal of Nanomedicine
, 12
pp. 6131-6152.
10.2147/IJN.S140772.
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Abstract
Development of multifunctional nanomaterials, one of the most interesting and advanced research areas in the field of nanotechnology, is anticipated to revolutionize cancer diagnosis and treatment. Gold nanoparticles (AuNPs) are now being widely utilized in bioimaging and phototherapy due to their tunable and highly sensitive optical and electronic properties (the surface plasmon resonance). As a new concept, termed “theranostics,” multifunctional AuNPs may contain diagnostic and therapeutic functions that can be integrated into one system, thereby simultaneously facilitating diagnosis and therapy and monitoring therapeutic responses. In this review, the important properties of AuNPs relevant to diagnostic and phototherapeutic applications such as structure, shape, optics, and surface chemistry are described. Barriers for translational development of theranostic AuNPs and recent advances in the application of AuNPs for cancer diagnosis, photothermal, and photodynamic therapy are discussed.
| Type: | Article |
|---|---|
| Title: | Gold nanoparticles enlighten the future of cancer theranostics |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.2147/IJN.S140772 |
| Publisher version: | http://dx.doi.org/10.2147/IJN.S140772 |
| Language: | English |
| Additional information: | This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms. |
| Keywords: | Multifunctional gold nanoparticles, cancer bioimaging, cancer photothermal and photodynamic therapy, NEAR-INFRARED LIGHT, SCATTERING SUBMICROSCOPIC PARTICLES, ENHANCED PHOTOTHERMAL THERAPY, HIGHLY FLUORESCENT ANALOGS, SURFACE-PLASMON RESONANCE, NUCLEIC-ACID DELIVERY, IN-VIVO, PHOTODYNAMIC THERAPY, OPTICAL-PROPERTIES, SIRNA DELIVERY |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10040963 |
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