Simunovic, M;
Saric, A;
Henderson, JM;
Lee, KYC;
Voth, GA;
(2017)
Long-Range Organization of Membrane-Curving Proteins.
ACS Central Science
, 3
(12)
pp. 1246-1253.
10.1021/acscentsci.7b00392.
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Abstract
Biological membranes have a central role in mediating the organization of membrane-curving proteins, a dynamic process that has proven to be challenging to probe experimentally. Using atomic force microscopy, we capture the hierarchically organized assemblies of Bin/amphiphysin/Rvs (BAR) proteins on supported lipid membranes. Their structure reveals distinct long linear aggregates of proteins, regularly spaced by up to 300 nm. Employing accurate free-energy calculations from large-scale coarse-grained computer simulations, we found that the membrane mediates the interaction among protein filaments as a combination of short- and long-ranged interactions. The long-ranged component acts at strikingly long distances, giving rise to a variety of micron-sized ordered patterns. This mechanism may contribute to the long-ranged spatiotemporal control of membrane remodeling by proteins in the cell.
| Type: | Article |
|---|---|
| Title: | Long-Range Organization of Membrane-Curving Proteins |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1021/acscentsci.7b00392 |
| Publisher version: | http://doi.org/10.1021/acscentsci.7b00392 |
| Language: | English |
| Additional information: | This is an open access article published under a Creative Commons Attribution (CC-BY) License, which permits unrestricted use, distribution and reproduction in any medium, provided the author and source are cited. |
| Keywords: | Science & Technology, Physical Sciences, Chemistry, Multidisciplinary, Chemistry, CURVATURE-GENERATING PROTEINS, BAR PROTEINS, LIPID-BILAYERS, MEDIATED INTERACTIONS, STRUCTURAL BASIS, INCLUSIONS, AGGREGATION, ENDOPHILIN, AMPHIPHYSIN, FORCES |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences > Dept of Physics and Astronomy |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10041490 |
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