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Long-Range Organization of Membrane-Curving Proteins

Simunovic, M; Saric, A; Henderson, JM; Lee, KYC; Voth, GA; (2017) Long-Range Organization of Membrane-Curving Proteins. ACS Central Science , 3 (12) pp. 1246-1253. 10.1021/acscentsci.7b00392. Green open access

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Abstract

Biological membranes have a central role in mediating the organization of membrane-curving proteins, a dynamic process that has proven to be challenging to probe experimentally. Using atomic force microscopy, we capture the hierarchically organized assemblies of Bin/amphiphysin/Rvs (BAR) proteins on supported lipid membranes. Their structure reveals distinct long linear aggregates of proteins, regularly spaced by up to 300 nm. Employing accurate free-energy calculations from large-scale coarse-grained computer simulations, we found that the membrane mediates the interaction among protein filaments as a combination of short- and long-ranged interactions. The long-ranged component acts at strikingly long distances, giving rise to a variety of micron-sized ordered patterns. This mechanism may contribute to the long-ranged spatiotemporal control of membrane remodeling by proteins in the cell.

Type: Article
Title: Long-Range Organization of Membrane-Curving Proteins
Open access status: An open access version is available from UCL Discovery
DOI: 10.1021/acscentsci.7b00392
Publisher version: http://doi.org/10.1021/acscentsci.7b00392
Language: English
Additional information: This is an open access article published under a Creative Commons Attribution (CC-BY) License, which permits unrestricted use, distribution and reproduction in any medium, provided the author and source are cited.
Keywords: Science & Technology, Physical Sciences, Chemistry, Multidisciplinary, Chemistry, CURVATURE-GENERATING PROTEINS, BAR PROTEINS, LIPID-BILAYERS, MEDIATED INTERACTIONS, STRUCTURAL BASIS, INCLUSIONS, AGGREGATION, ENDOPHILIN, AMPHIPHYSIN, FORCES
UCL classification: UCL
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences > Dept of Physics and Astronomy
URI: https://discovery-pp.ucl.ac.uk/id/eprint/10041490
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