Haller, S;
Höller, C;
Jacobshagen, A;
Hamouda, O;
Abu Sin, M;
Monnet, DL;
Plachouras, D;
(2016)
Contamination during production of heater-cooler units by Mycobacterium chimaera potential cause for invasive cardiovascular infections: results of an outbreak investigation in Germany, April 2015 to February 2016.
Eurosurveillance
, 21
(17)
, Article 30215. 10.2807/1560-7917.ES.2016.21.17.30215.
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Abstract
Invasive infections with Mycobacterium chimaera were reported in patients with previous open chest surgery and exposure to contaminated heater-cooler units (HCUs). We present results of the surveillance of clinical cases and of contaminated HCUs as well as environmental investigations in Germany up until February 2016. Clinical infections occurred in five male German cases over 50 years of age (range 53-80). Cases had been exposed to HCUs from one single manufacturer during open chest surgery up to five years prior to onset of symptoms. During environmental investigations, M. chimaera was detected in samples from used HCUs from three different countries and samples from new HCUs as well as in the environment at the manufacturing site of one manufacturer in Germany. Our investigation suggests that at least some of the M. chimaera infections may have been caused by contamination of HCUs at manufacturing site. We recommend that until sustainable measures for safe use of HCUs in operation theatres are implemented, users continue to adhere to instructions for use of HCUs and Field Safety Notices issued by the manufacturer, implement local monitoring for bacterial contamination and continuously check the websites of national and European authorities for current recommendations for the safe operation of HCUs.
| Type: | Article |
|---|---|
| Title: | Contamination during production of heater-cooler units by Mycobacterium chimaera potential cause for invasive cardiovascular infections: results of an outbreak investigation in Germany, April 2015 to February 2016 |
| Location: | Sweden |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.2807/1560-7917.ES.2016.21.17.30215 |
| Publisher version: | http://doi.org/10.2807/1560-7917.ES.2016.21.17.302... |
| Language: | English |
| Additional information: | This is an open-access article distributed under the terms of the Creative Commons Attribution (CC BY 4.0) Licence. You may share and adapt the material, but must give appropriate credit to the source, provide a link to the licence, and indicate if changes were made. This article is copyright of the authors, 2016. |
| Keywords: | Heater-Cooler Units, Mycobacterium chimaera, international, outbreak, Aged, Aged, 80 and over, Cardiac Surgical Procedures, Comorbidity, Disease Outbreaks, Equipment Contamination, Extracorporeal Circulation, Germany, Humans, Male, Middle Aged, Mycobacterium, Mycobacterium Infections, Myocarditis, Population Surveillance, Prevalence, Surgical Wound Infection, Vasculitis |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10042327 |
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