Thom, M;
(2018)
New Perspectives in Epilepsy Neuropathology.
Neuropathology and Applied Neurobiology
, 44
(1)
pp. 3-5.
10.1111/nan.12464.
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Abstract
As epilepsy surgery programmes commenced in the 1950s, many eminent neuropathologists embraced the opportunity to study the varied lesions identified in relation to electroencephalography, neuroimaging, psychometry as well as outcome following removal of what was termed the 'alien' brain tissue [1-3]. Beyond their insightful and meticulous histological descriptions, they began to address the questions of what caused these lesions, how they gave rise to epilepsy (the processes of 'epileptogensis') and how they related to other co-morbidities or mortality associated with epilepsy. Now in 2018 we have built on these foundations and, through the evidence amassed from decades of experience, there is greater confidence that resective surgery is a current treatment of choice in selected patients with refractory focal epilepsies.
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