Rusbridge, C;
Salguero, FJ;
David, MA;
Faller, KME;
Bras, JT;
Guerreiro, RJ;
Richard-Londt, AC;
... Tayebi, M; + view all
(2018)
An Aged Canid with Behavioral Deficits Exhibits Blood and Cerebrospinal Fluid Amyloid Beta Oligomers.
Frontiers in Aging Neuroscience
, 10
, Article 7. 10.3389/fnagi.2018.00007.
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Abstract
Many of the molecular and pathological features associated with human Alzheimer disease (AD) are mirrored in the naturally occurring age-associated neuropathology in the canine species. In aged dogs with declining learned behavior and memory the severity of cognitive dysfunction parallels the progressive build up and location of Aβ in the brain. The main aim of this work was to study the biological behavior of soluble oligomers isolated from an aged dog with cognitive dysfunction through investigating their interaction with a human cell line and synthetic Aβ peptides. We report that soluble oligomers were specifically detected in the dog's blood and cerebrospinal fluid (CSF) via anti-oligomer- and anti-Aβ specific binders. Importantly, our results reveal the potent neurotoxic effects of the dog's CSF on cell viability and the seeding efficiency of the CSF-borne soluble oligomers on the thermodynamic activity and the aggregation kinetics of synthetic human Aβ. The value of further characterizing the naturally occurring Alzheimer-like neuropathology in dogs using genetic and molecular tools is discussed.
| Type: | Article |
|---|---|
| Title: | An Aged Canid with Behavioral Deficits Exhibits Blood and Cerebrospinal Fluid Amyloid Beta Oligomers |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.3389/fnagi.2018.00007 |
| Publisher version: | http://dx.doi.org/10.3389/fnagi.2018.00007 |
| Language: | English |
| Additional information: | © 2018 Rusbridge, Salguero, David, Faller, Bras, Guerreiro, Richard-Londt, Grainger, Head, Brandner, Summers, Hardy and Tayebi. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
| Keywords: | Science & Technology, Life Sciences & Biomedicine, Geriatrics & Gerontology, Neurosciences, Neurosciences & Neurology, canine cognitive dysfunction, Alzheimer, canine, A beta oligomers, neuropathology, aggregation, neurotoxicity, ALZHEIMERS-DISEASE, BRAIN, DOGS, ANTIBODIES, PROTEINS, PATHWAY, MODEL |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Neurodegenerative Diseases |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10043459 |
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