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Chapter 6 - Cerebrospinal fluid in the dementias

Zetterberg, H; Rohrer, JD; Schott, JM; (2017) Chapter 6 - Cerebrospinal fluid in the dementias. Handbook of Clinical Neurology , 146 pp. 85-97. 10.1016/B978-0-12-804279-3.00006-X.

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Abstract

Alzheimer disease, vascular dementia, dementia with Lewy bodies, and frontotemporal dementia are the most common central nervous system disorders that cause progressive neurocognitive dysfunction and ultimately dementia. A number of biomarkers for pathologies reflecting each condition have been developed. Here, we review these and give an overview of the current state of practice and research regarding cerebrospinal fluid biomarkers for these disorders. The chapter discusses both established (most of which are tau- and amyloid β-related) and upcoming biomarkers and details, wherever appropriate, clinical use and differential diagnostics aspects.

Type: Article
Title: Chapter 6 - Cerebrospinal fluid in the dementias
Location: Netherlands
DOI: 10.1016/B978-0-12-804279-3.00006-X
Publisher version: http://doi.org/10.1016/B978-0-12-804279-3.00006-X
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Alzheimer's disease, Biomarkers, amyloid, cerebrospinal fluid, dementia, dementia with Lewy bodies, frontotemporal dementia, tau, vascular dementia
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Neurodegenerative Diseases
URI: https://discovery-pp.ucl.ac.uk/id/eprint/10043513
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