Lucendo-Villarin, B;
Rashidi, H;
Cameron, K;
Hay, DC;
(2016)
Pluripotent stem cell derived hepatocytes: using materials to define cellular differentiation and tissue engineering.
Journal Of Materials Chemistry B
, 4
(20)
pp. 3433-3442.
10.1039/c6tb00331a.
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Abstract
Pluripotent stem cell derived liver cells (hepatocytes) represent a promising alternative to primary tissue for biological and clinical applications. To date, most hepatocyte maintenance and differentiation systems have relied upon the use of animal derived components. This serves as a significant barrier to large scale production and application of stem cell derived hepatocytes. Recently, the use of defined biologics has overcome those limitations in two-dimensional monolayer culture. In order to improve the cell phenotype further, three-dimensional culture systems have been employed to better mimic the in vivo situation, drawing upon materials chemistry, engineering and biology. In this review we discuss efforts in the field, to differentiate pluripotent stem cells towards hepatocytes under defined conditions.
| Type: | Article |
|---|---|
| Title: | Pluripotent stem cell derived hepatocytes: using materials to define cellular differentiation and tissue engineering |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1039/c6tb00331a |
| Publisher version: | http://dx.doi.org/10.1039/c6tb00331a |
| Language: | English |
| Additional information: | This article is licensed under a Creative Commons Attribution 3.0 Unported Licence (http://creativecommons.org/licenses/by/3.0/). |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Developmental Biology and Cancer Dept |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10044267 |
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