Simitzi, C;
Harimech, P;
Spanou, S;
Lanara, C;
Heuer-Jungemann, A;
Manousaki, A;
Fotakis, C;
... Stratakis, E; + view all
(2018)
Cells on hierarchically-structured platforms hosting functionalized nanoparticles.
Biomaterials Science
, 2018
(6)
pp. 1469-1479.
10.1039/C7BM00904F.
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Abstract
In this work, we report on a novel approach to develop hierarchically-structured cell culture platforms incorporating functionalized gold nanoparticles (AuNPs). In particular, the hierarchical substrates comprise primary pseudo-periodic arrays of silicon microcones combined with a secondary nanoscale pattern of homogenously deposited AuNPs terminated with bio-functional moieties. AuNPs with various functionalities (i.e. oligopeptides, small molecules and oligomers) were successfully attached onto the microstructures. Experiments with PC12 cells on the hierarchical substrates incorporating AuNPs carrying the RGD peptide showed an impressive growth and NGF-induced differentiation of the PC12 cells, compared to that on the NPs-free, bare, micropatterned substrates. The exploitation of the developed methodology for the binding of AuNPs as carriers of specific bio-functional moieties onto micropatterned culture substrates for cell biology studies is envisaged.
| Type: | Article |
|---|---|
| Title: | Cells on hierarchically-structured platforms hosting functionalized nanoparticles |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1039/C7BM00904F |
| Publisher version: | https://doi.org/10.1039/C7BM00904F |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences > MAPS Faculty Office UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences > MAPS Faculty Office > Institute for Materials Discovery |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10045300 |
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