Amos, R;
Bulbeck, H;
Burnet, N;
Crellin, A;
Eaton, D;
Evans, P;
Hall, E;
... Sharma, RA; + view all
(2018)
Proton Beam Therapy – the Challenges of Delivering High-quality Evidence of Clinical Benefit.
Clinical Oncology
, 30
(5)
10.1016/j.clon.2018.02.031.
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Abstract
The use of proton beam therapy (PBT) offers the opportunity to improve greater conformality of radiotherapy treatment delivery in some patients. However, it is associated with a high capital cost and the need to build new dedicated facilities. We discuss how the global radiotherapy community can respond to the challenge of producing high-quality evidence of clinical benefit from PBT in adult patients. In the UK, the National Cancer Research Institute-funded Clinical and Radiotherapy Translational group has established the PBT Clinical Trial Strategy Group. An eight-point framework is described that can assist the development and delivery of high-quality clinical trials.
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