Tomkins-Netzer, O;
Leong, BCS;
Zhang, XZ;
Lightman, S;
McCluskey, PJ;
Lee, AJ;
Leahy, K;
... Sydney-London Latent Ocular TB Study Group, .; + view all
(2018)
Effect of Anti-Tuberculous Therapy on Uveitis Associated with Latent Tuberculosis.
American Journal of Ophthalmology
, 190
pp. 164-170.
10.1016/j.ajo.2018.03.032.
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Abstract
PURPOSE: To describe the clinical features of patients with uveitis associated with latent tuberculosis (TB) and examine the effect of anti-TB treatment (ATT) on uveitis outcome. DESIGN: Retrospective cohort study METHODS: 199 eyes of 129 patients diagnosed with uveitis associated with latent TB were evaluated for recurrence of disease following treatment. Eighty nine of the patients (69%) received ATT and information was gathered retrospectively regarding clinical outcome, vision and treatment. Outcome measures included: best corrected visual acuity (BCVA) and rate of disease recurrence. RESULTS: This study included eighty-nine patients (69%) received ATT and 40 patients who did not. The uveitis was treated with local and systemic anti-inflammatory and immunosuppressive therapy in all patients. The mean change in BCVA following treatment was 4.5±1.4 letters over the follow-up period, with no difference between eyes of patients receiving ATT and those who did not. Sixty-eight eyes (34.9%) had a recurrence of uveitis (0.64±0.08 recurrences per-year), with eyes of patients receiving ATT less likely to develop a recurrence compared to those not receiving ATT (29.5% vs. 48.2%, OR 0.47, 95% CI 0.29-0.77, p=0.003). Eyes treated with ATT recurred at an estimated median of 120 months compared with 51 months in eyes with no treatment (p=0.005). CONCLUSIONS: Treatment with ATT halved the risk of uveitis recurrence and delayed the onset of the first recurrence in eyes with uveitis associated with latent TB.
| Type: | Article |
|---|---|
| Title: | Effect of Anti-Tuberculous Therapy on Uveitis Associated with Latent Tuberculosis |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.ajo.2018.03.032 |
| Publisher version: | https://doi.org/10.1016/j.ajo.2018.03.032 |
| Language: | English |
| Additional information: | © 2018 Elsevier Inc. All rights reserved. This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Ophthalmology |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10046305 |
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