Perera, AS;
Zhang, S;
Homer-Vanniasinkam, S;
Coppens, M-O;
Edirisinghe, M;
(2018)
Polymer-Magnetic Composite Fibers for Remote-Controlled Drug Release.
Applied Materials and Interfaces
, 10
(18)
pp. 15524-15531.
10.1021/acsami.8b04774.
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Abstract
An efficient method is reported, for fabrication of composite microfibers that can be magnetically actuated and are biocompatible, targeting controlled drug release. Aqueous solutions of polyvinyl alcohol (PVA), incorporated with citric acid coated Fe3O4 magnetic nanoparticles (MNPs), are subject to infusion gyration, to generate 100-300 nm diameter composite fibers, with controllable MNP loading. The fibers are stable in polar solvents, such as ethanol, and do not show any leaching of MNPs for over 4 weeks. Using acetaminophen as an example, we demonstrate that, this material is effective in immobilization and triggered release of drugs, achieved by a moving external magnetic field. The remote actuation ability, coupled with biocompatibility and lightweight property, renders enormous potential for these fibers to be used as a smart drug-release agent.
| Type: | Article |
|---|---|
| Title: | Polymer-Magnetic Composite Fibers for Remote-Controlled Drug Release |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1021/acsami.8b04774 |
| Publisher version: | http://doi.org/10.1021/acsami.8b04774 |
| Language: | English |
| Additional information: | This is an open access article published under a Creative Commons Attribution (CC-BY) License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium, provided the author and source are cited. |
| Keywords: | Nanofibers, nanomaterials, polymer-magnetic composites, magnetic actuation, controlled drug release, infusion gyration |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Chemical Engineering UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Mechanical Engineering |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10047431 |
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