Chapman, CAR;
Goshi, N;
Seker, E;
(2018)
Multifunctional Neural Interfaces for Closed-Loop Control of Neural Activity.
Advanced Functional Materials
, 28
(12)
, Article 1703523. 10.1002/adfm.201703523.
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Abstract
Microfabrication and nanotechnology have significantly expanded the technological capabilities for monitoring and modulating neural activity with the goal of studying the nervous system and managing neurological disorders. This feature article initially provides a tutorial‐like review of the prominent technologies for enabling this two‐way communication with the nervous system via electrical, chemical, and optical means. Following this overview, the article discusses emerging high‐throughput methods for identifying device attributes that enhance the functionality of interfaces. The discussion then extends into opportunities and challenges in integrating different device functions within a small footprint with the goal of closed‐loop control of neural activity with high spatiotemporal resolution and reduced adverse tissue response. The article concludes with an outline of future directions in the development and applications of multifunctional neural interfaces.
| Type: | Article |
|---|---|
| Title: | Multifunctional Neural Interfaces for Closed-Loop Control of Neural Activity |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1002/adfm.201703523 |
| Publisher version: | https://doi.org/10.1002/adfm.201703523 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | neural interfaces, microfabrication, nanotechnology, high-throughput screening, closed-loop control |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10047723 |
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