Freedman, SL;
Banerjee, S;
Hocky, GM;
Dinner, AR;
(2017)
A Versatile Framework for Simulating the Dynamic Mechanical Structure of Cytoskeletal Networks.
Biophysical Journal
, 113
(2)
pp. 448-460.
10.1016/j.bpj.2017.06.003.
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Abstract
Computer simulations can aid in understanding how collective materials properties emerge from interactions between simple constituents. Here, we introduce a coarse-grained model that enables simulation of networks of actin filaments, myosin motors, and cross-linking proteins at biologically relevant time and length scales. We demonstrate that the model qualitatively and quantitatively captures a suite of trends observed experimentally, including the statistics of filament fluctuations, and mechanical responses to shear, motor motilities, and network rearrangements. We use the simulation to predict the viscoelastic scaling behavior of cross-linked actin networks, characterize the trajectories of actin in a myosin motility assay, and develop order parameters to measure contractility of a simulated actin network. The model can thus serve as a platform for interpretation and design of cytoskeletal materials experiments, as well as for further development of simulations incorporating active elements.
| Type: | Article |
|---|---|
| Title: | A Versatile Framework for Simulating the Dynamic Mechanical Structure of Cytoskeletal Networks |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.bpj.2017.06.003 |
| Publisher version: | https://doi.org/10.1016/j.bpj.2017.06.003 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Science & Technology, Life Sciences & Biomedicine, Biophysics,Single Actin-Filaments, Myosin-II, In-Vitro, Actomyosin Networks, Persistence Length, Skeletal-Muscle, Motility Assays, Motor Proteins, Smooth-Muscle, Contractility |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10047950 |
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