Möbius, M;
Lacomblé, L;
Meyer, T;
Schutter, DJLG;
Gielkens, T;
Becker, ES;
Tendolkar, I;
(2016)
Repetitive transcranial magnetic stimulation modulates the impact of a negative mood induction.
Social Cognitive and Affective Neuroscience
, 12
(4)
pp. 526-533.
10.1093/scan/nsw180.
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Abstract
High frequency repetitive Transcranial Magnetic Stimulation (rTMS) over the left dorsolateral prefrontal cortex (DLPFC) has been found to alleviate depressive symptoms. However, the mechanisms driving these effects are still poorly understood. In the current study, we tested the idea that this intervention protects against negative mood shifts following emotional provocation. We furthermore explored changes in EEG activity (frontal alpha asymmetry) and effects on attentional processing (emotional Stroop). To this end, 23 healthy individuals participated in two sessions separated by one week, whereby they once received 15 min of 10Hz rTMS stimulation (1500 pulses) at 110% of the individual motor threshold, and once sham stimulation. Then, negative mood was induced using sad movie clips. The results revealed a significantly stronger mood decline following rTMS compared to sham stimulation. No changes were observed in frontal alpha asymmetry and attentional processing. Our findings are at odds with the view that high frequency rTMS over the left DLPFC directly protects against the induction of negative mood, but rather suggest that it enhances the effects of emotional provocation. Possibly, in healthy young individuals, this stimulation protocol heightens susceptibility to mood induction procedures in general.
| Type: | Article |
|---|---|
| Title: | Repetitive transcranial magnetic stimulation modulates the impact of a negative mood induction |
| Location: | England |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1093/scan/nsw180 |
| Publisher version: | https://doi.org/10.1093/scan/nsw180 |
| Language: | English |
| Additional information: | This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/ licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com |
| Keywords: | DLPFC, alpha asymmetry, depression, negative mood induction, repetitive Transcranial Magnetic Stimulation, Adult, Affect, Alpha Rhythm, Attention, Depression, Dominance, Cerebral, Facial Expression, Female, Frontal Lobe, Humans, Male, Netherlands, Prefrontal Cortex, Reaction Time, Stroop Test, Transcranial Magnetic Stimulation, Young Adult |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences > Clinical, Edu and Hlth Psychology |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10049311 |
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