Page, KM; Perez-Carrasco, R; (2018) Degradation rate uniformity determines success of oscillations in repressive feedback regulatory networks. Journal of the Royal Society Interface , 15 (142) , Article 20180157. 10.1098/rsif.2018.0157.

Preview

Text Page_Degradation rate uniformity determines success of oscillations in repressive feedback regulatory networks_VoR.pdf - Published Version Download (748kB) | Preview

Abstract

Ring oscillators are biochemical circuits consisting of a ring of interactions capable of sustained oscillations. The nonlinear interactions between genes hinder the analytical insight into their function, usually requiring computational exploration. Here, we show that, despite the apparent complexity, the stability of the unique steady state in an incoherent feedback ring depends only on the degradation rates and a single parameter summarizing the feedback of the circuit. Concretely, we show that the range of regulatory parameters that yield oscillatory behaviour is maximized when the degradation rates are equal. Strikingly, this result holds independently of the regulatory functions used or number of genes. We also derive properties of the oscillations as a function of the degradation rates and number of nodes forming the ring. Finally, we explore the role of mRNA dynamics by applying the generic results to the specific case with two naturally different degradation timescales.

Download activity - last month

Export as JSONXMLCSV

Download activity - last 12 months

Export as JSONXMLCSV

Downloads by country - last 12 months

Export as JSONXMLCSV

Archive Staff Only

View Item