Rodrigues, FB;
Byrne, LM;
Wild, EJ;
(2018)
Biofluid Biomarkers in Huntington's Disease.
In: Precious, SV and Rosser, AE and Dunnett, SB, (eds.)
Huntington’s Disease.
(pp. 329-396).
Humana Press: New York, NY, USA.
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Abstract
Huntington's disease (HD) is a chronic progressive neurodegenerative condition where new markers of disease progression are needed. So far no disease-modifying interventions have been found, and few interventions have been proven to alleviate symptoms. This may be partially explained by the lack of reliable indicators of disease severity, progression, and phenotype.Biofluid biomarkers may bring advantages in addition to clinical measures, such as reliability, reproducibility, price, accuracy, and direct quantification of pathobiological processes at the molecular level; and in addition to empowering clinical trials, they have the potential to generate useful hypotheses for new drug development.In this chapter we review biofluid biomarker reports in HD, emphasizing those we feel are likely to be closest to clinical applicability.
| Type: | Book chapter |
|---|---|
| Title: | Biofluid Biomarkers in Huntington's Disease |
| ISBN-13: | 978-1-4939-7824-3 |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1007/978-1-4939-7825-0_17 |
| Publisher version: | https://doi.org/10.1007/978-1-4939-7825-0_17 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Biomarkers, Blood, Cerebrospinal fluid, Huntington’s disease, Review, Urine, Biomarkers, Body Fluids, Brain, Drug Development, Humans, Huntingtin Protein, Huntington Disease, Inflammation Mediators, Neurons, Neurotransmitter Agents, Oxidative Stress, Proteomics, Transglutaminases |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Neurodegenerative Diseases |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10049810 |
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