Young, LC;
Rodriguez-Viciana, P;
(2018)
MRAS: A Close but Understudied Member of the RAS Family.
Cold Spring Harb Perspect Med
10.1101/cshperspect.a033621.
(In press).
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Rodriguez-Viciana_MRAS. A Close but Understudied Member of the RAS family_.pdf - Accepted Version Download (139kB) | Preview |
Abstract
MRAS is the closest relative to the classical RAS oncoproteins and shares most regulatory and effector interactions. However, it also has unique functions, including its ability to function as a phosphatase regulatory subunit when in complex with SHOC2 and protein phosphatase 1 (PP1). This phosphatase complex regulates a crucial step in the activation cycle of RAF kinases and provides a key coordinate input required for efficient ERK pathway activation and transformation by RAS. MRAS mutations rarely occur in cancer but deregulated expression may play a role in tumorigenesis in some settings. Activating mutations in MRAS (as well as SHOC2 and PP1) do occur in the RASopathy Noonan syndrome, underscoring a key role for MRAS within the RAS-ERK pathway. MRAS also has unique roles in cell migration and differentiation and has properties consistent with a key role in the regulation of cell polarity. Further investigations should shed light on what remains a relatively understudied RAS family member.
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