Jiménez, JP;
Botto, A;
Herrera, L;
Leighton, C;
Rossi, JL;
Quevedo, Y;
Silva, J;
... Luyten, PJ; + view all
(2018)
Psychotherapy and genetic neuroscience: an emerging dialogue.
Frontiers in Genetics
, 9
, Article 257. 10.3389/fgene.2018.00257.
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Abstract
Recent research in psychiatric genetics has led to a move away from simple diathesis-stress models to more complex models of psychopathology incorporating a focus on gene-environment interactions and epigenetics. Our increased understanding of the way biology encodes the impact of life events on organisms has also generated more sophisticated theoretical models concerning the molecular processes at the interface between "nature" and "nurture". There is also increasing consensus that psychotherapy entails a specific type of learning in the context of an emotional relationship (i.e., the therapeutic relationship) that may also lead to epigenetic modifications across different therapeutic treatment modalities. This paper provides a systematic review of this emerging body of research. It is concluded that, although the evidence is still limited at this stage, extant research does indeed suggest that psychotherapy may be associated with epigenetic changes. Furthermore, it is argued that epigenetic studies may play a key role in the identification of biomarkers implicated in vulnerability for psychopathology, and thus may improve diagnosis and open up future research opportunities regarding the mechanism of action of psychotropic drugs as well as psychotherapy. We review evidence suggesting there may be important individual differences in susceptibility to environmental input, including psychotherapy. In addition, given that there is increasing evidence for the transgenerational transmission of epigenetic modifications in animals and humans exposed to trauma and adversity, epigenetic changes produced by psychotherapy may also potentially be passed on to the next generation, which opens up new perspective for prevention science. We conclude this paper stressing the limitations of current research and by proposing a set of recommendations for future research in this area.
| Type: | Article |
|---|---|
| Title: | Psychotherapy and genetic neuroscience: an emerging dialogue |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.3389/fgene.2018.00257 |
| Publisher version: | https://doi.org/10.3389/fgene.2018.00257 |
| Language: | English |
| Additional information: | Copyright: © 2018 Jimenez, Botto, Herrera, Leighton, Rossi, Quevedo, Silva, Martinez, Assar, Salazar, Ortiz, Rios, Barros, Jaramillo and Luyten. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (http://creativecommons.org/licenses/by/4.0/). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
| Keywords: | Gene-environment interactions, Epigenetic modifications, Subjective experience, Psychopathology, Psychotherapeutic change |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences > Clinical, Edu and Hlth Psychology |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10051166 |
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