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Thalamic nuclei convey diverse contextual information to layer 1 of visual cortex

Roth, MM; Dahmen, JC; Muir, DR; Imhof, F; Martini, FJ; Hofer, SB; (2016) Thalamic nuclei convey diverse contextual information to layer 1 of visual cortex. Nature Neuroscience , 19 (2) pp. 299-307. 10.1038/nn.4197. Green open access

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Abstract

Sensory perception depends on the context in which a stimulus occurs. Prevailing models emphasize cortical feedback as the source of contextual modulation. However, higher order thalamic nuclei, such as the pulvinar, interconnect with many cortical and subcortical areas, suggesting a role for the thalamus in providing sensory and behavioral context. Yet the nature of the signals conveyed to cortex by higher order thalamus remains poorly understood. Here we use axonal calcium imaging to measure information provided to visual cortex by the pulvinar equivalent in mice, the lateral posterior nucleus (LP), as well as the dorsolateral geniculate nucleus (dLGN). We found that dLGN conveys retinotopically precise visual signals, while LP provides distributed information from the visual scene. Both LP and dLGN projections carry locomotion signals. However, while dLGN inputs often respond to positive combinations of running and visual flow speed, LP signals discrepancies between self-generated and external visual motion. This higher order thalamic nucleus therefore conveys diverse contextual signals that inform visual cortex about visual scene changes not predicted by the animal's own actions

Type: Article
Title: Thalamic nuclei convey diverse contextual information to layer 1 of visual cortex
Open access status: An open access version is available from UCL Discovery
DOI: 10.1038/nn.4197
Publisher version: https://doi.org/10.1038/nn.4197
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > The Sainsbury Wellcome Centre
URI: https://discovery-pp.ucl.ac.uk/id/eprint/10051338
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