MacDonell, CW;
Chopek, JW;
Gardiner, KR;
Gardiner, PF;
(2017)
alpha-Motoneurons maintain biophysical heterogeneity in obesity and diabetes in Zucker rats.
Journal of Neurophysiology
, 118
(4)
pp. 2318-2327.
10.1152/jn.00423.2017.
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Abstract
Small-diameter sensory dysfunction resulting from diabetes has received much attention in the literature, whereas the impact of diabetes on α-motoneurons (MN) has not. In addition, the chance of developing insulin resistance and diabetes is increased in obesity. No study has examined the impact of obesity or diabetes on the biophysical properties of MN. Lean Zucker rats and Zucker diabetic fatty (ZDF) rats were separated into lean, obese (ZDF fed standard chow), and diabetic (ZDF fed high-fat diet that led to diabetes) groups. Glass micropipettes recorded hindlimb MN properties from identified flexor and extensor MN. MN were separated within their groups on the basis of input conductance, which created high- and low-input conductance subpopulations for each. A significant shorter (20%) afterhyperpolarization half-decay (AHP1/2) was found in low-conductance MN for the diabetic group only, whereas AHP½ tended to be shorter in the obese group (19%). Significant positive correlations were found among rheobase and input conductance for both lean and obese animals. No differences were found between the groups for afterhyperpolarization amplitude (AHPamp), input conductance, rheobase, or any of the rhythmic firing properties (frequency-current slope and spike-frequency adaptation index). MN properties continue to be heterogeneous in obese and diabetic animals. Obesity does not seem to influence lumbar MN. Despite the resistance of MN to the impact of diabetes, the reduced AHP1/2 decay and the tendency for a reduction in AHPamp may be the first sign of change to MN function.
| Type: | Article |
|---|---|
| Title: | alpha-Motoneurons maintain biophysical heterogeneity in obesity and diabetes in Zucker rats |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1152/jn.00423.2017 |
| Publisher version: | https://doi.org/10.1152/jn.00423.2017 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Science & Technology, Life Sciences & Biomedicine, Neurosciences, Physiology, Neurosciences & Neurology, motoneuron, obesity, diabetes, electrophysiology, neurophysiology, SPINAL-CORD TRANSECTION, MOTOR-UNIT TYPE, TIME-COURSE, HINDLIMB MOTONEURONS, CONDUCTION-VELOCITY, ELECTROPHYSIOLOGICAL PROPERTIES, PHYSIOLOGICAL-PROPERTIES, FICTIVE LOCOMOTION, INSULIN-RESISTANCE, ADOLESCENT GIRLS |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10051652 |
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