Frässle, S;
Lomakina, EI;
Kasper, L;
Manjaly, ZM;
Leff, A;
Pruessmann, KP;
Buhmann, JM;
(2018)
A generative model of whole-brain effective connectivity.
Neuroimage
, 179
pp. 505-529.
10.1016/j.neuroimage.2018.05.058.
Preview |
Text
Leff_A generative model of whole-brain effective connectivity_VoR.pdf - Published Version Download (4MB) | Preview |
Abstract
The development of whole-brain models that can infer effective (directed) connection strengths from fMRI data represents a central challenge for computational neuroimaging. A recently introduced generative model of fMRI data, regression dynamic causal modeling (rDCM), moves towards this goal as it scales gracefully to very large networks. However, large-scale networks with thousands of connections are difficult to interpret; additionally, one typically lacks information (data points per free parameter) for precise estimation of all model parameters. This paper introduces sparsity constraints to the variational Bayesian framework of rDCM as a solution to these problems in the domain of task-based fMRI. This sparse rDCM approach enables highly efficient effective connectivity analyses in whole-brain networks and does not require a priori assumptions about the network's connectivity structure but prunes fully (all-to-all) connected networks as part of model inversion. Following the derivation of the variational Bayesian update equations for sparse rDCM, we use both simulated and empirical data to assess the face validity of the model. In particular, we show that it is feasible to infer effective connection strengths from fMRI data using a network with more than 100 regions and 10,000 connections. This demonstrates the feasibility of whole-brain inference on effective connectivity from fMRI data – in single subjects and with a run-time below 1 min when using parallelized code. We anticipate that sparse rDCM may find useful application in connectomics and clinical neuromodeling – for example, for phenotyping individual patients in terms of whole-brain network structure.
| Type: | Article |
|---|---|
| Title: | A generative model of whole-brain effective connectivity |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.neuroimage.2018.05.058 |
| Publisher version: | https://doi.org/10.1016/j.neuroimage.2018.05.058 |
| Language: | English |
| Additional information: | © 2018 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode). |
| Keywords: | Bayesian regression, Dynamic causal modeling, Generative model, Effective connectivity, Sparsity, Connectomics |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Brain Repair and Rehabilitation |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10052885 |
Archive Staff Only
 |
View Item |
