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Exogenous dopamine reduces GABA receptor availability in the human brain

Lou, HC; Rosenstand, A; Brooks, DJ; Bender, D; Jakobsen, S; Blicher, JU; Hansen, KV; (2016) Exogenous dopamine reduces GABA receptor availability in the human brain. Brain and Behavior , 6 (7) , Article e00484. 10.1002/brb3.484. Green open access

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Abstract

Background: While it has recently been shown that dopamine release stimulates conscious self‐monitoring through the generation of gamma oscillations in medial prefrontal/anterior cingulate cortex, and that the GABAergic system is effective in producing such oscillations, interaction of the two transmitter systems has not been demonstrated in humans. We here hypothesize that dopamine challenge stimulates the GABA system directly in the medial prefrontal/anterior cingulate region in the human brain. // Methods: Positron emission tomography (PET) with the GABA receptor α1/α5 subtype ligand [11C] Ro15‐4513 was used to detect changes in GABA receptor availability after clinical oral doses of levodopa in a double blind controlled study. // Results: We here provide the first direct evidence for such coupling in the cerebral cortex, in particular in the medial prefrontal anterior cingulate region, by showing that exogenous dopamine decreases [11C] Ro15‐4513 binding widely in the human brain compatible with a fall in α1 subtype availability in GABA complexes due to increased GABA activity.

Type: Article
Title: Exogenous dopamine reduces GABA receptor availability in the human brain
Open access status: An open access version is available from UCL Discovery
DOI: 10.1002/brb3.484
Publisher version: https://doi.org/10.1002/brb3.484
Language: English
Additional information: © 2016 The Authors. This is an open access article under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Keywords: Dopamine, GABA, insula, medial prefrontal/anterior cingulate, self-awareness
URI: https://discovery-pp.ucl.ac.uk/id/eprint/10053396
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