Rosen, CL;
Debaun, MR;
Strunk, RC;
Redline, S;
Seicean, S;
Craven, DI;
Gavlak, JCD;
... Kirkham, FJ; + view all
(2014)
Obstructive Sleep Apnea and Sickle Cell Anemia.
Pediatrics
, 134
(2)
pp. 273-281.
10.1542/peds.2013-4223.
Preview |
Text
Kirkham_OSA Prevalence SAC Draft_2014Mar16 MR fjk.pdf - Accepted Version Download (746kB) | Preview |
Abstract
OBJECTIVE: To ascertain the prevalence of and risk factors for obstructive sleep apnea syndrome (OSAS) in children with sickle cell anemia (SCA). METHODS: Cross-sectional baseline data were analyzed from the Sleep and Asthma Cohort Study, a multicenter prospective study designed to evaluate the contribution of sleep and breathing abnormalities to SCA-related morbidity in children ages 4 to 18 years, unselected for OSAS symptoms or asthma. Multivariable logistic regression assessed the relationships between OSAS status on the basis of overnight in-laboratory polysomnography and putative risk factors obtained from questionnaires and direct measurements. RESULTS: Participants included 243 children with a median age of 10 years; 50% were boys, 99% were of African heritage, and 95% were homozygous for βS hemoglobin. OSAS, defined by obstructive apnea hypopnea indices, was present in 100 (41%) or 25 (10%) children at cutpoints of ≥1 or ≥5, respectively. In univariate analyses, OSAS was associated with higher levels of habitual snoring, lower waking pulse oxygen saturation (Spo2), reduced lung function, less caretaker education, and non–preterm birth. Lower sleep-related Spo2 metrics were also associated with higher obstructive apnea hypopnea indices. In multivariable analyses, habitual snoring and lower waking Spo2 remained risk factors for OSAS in children with SCA. CONCLUSIONS: The prevalence of OSAS in children with SCA is higher than in the general pediatric population. Habitual snoring and lower waking Spo2 values, data easily obtained in routine care, were the strongest OSAS risk factors. Because OSAS is a treatable condition with adverse health outcomes, greater efforts are needed to screen, diagnose, and treat OSAS in this high-risk, vulnerable population.
| Type: | Article |
|---|---|
| Title: | Obstructive Sleep Apnea and Sickle Cell Anemia |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1542/peds.2013-4223 |
| Publisher version: | https://doi.org/10.1542/peds.2013-4223 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Science & Technology, Life Sciences & Biomedicine, Pediatrics, sickle cell anemia, obstructive sleep apnea, polysomnography, sleep disorders, epidemiology, cohort study, blood disorders, sleep medicine,school-aged children, attention-deficit/hyperactivity disorder, risk-factors, pulse oximetry, polysomnographic characteristics, oxygen desaturation, natural-history, disease, asthma, adolescents |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Developmental Neurosciences Dept |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10053431 |
Archive Staff Only
 |
View Item |
