Mandala, WL;
Gondwe, EN;
Molyneux, ME;
MacLennan, JM;
MacLennan, CA;
(2017)
Leukocyte counts and lymphocyte subsets in relation to pregnancy and HIV infection in Malawian women.
American Journal of Reproductive Immunology
, 78
(3)
, Article e12678. 10.1111/aji.12678.
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Abstract
PROBLEM: We investigated leukocyte and lymphocyte subsets in HIV-infected or HIV-uninfected, pregnant or non-pregnant Malawian women to explore whether HIV infection and pregnancy may act synergistically to impair cellular immunity. METHOD OF STUDY: We recruited 54 pregnant and 48 non-pregnant HIV-uninfected women and 24 pregnant and 20 non-pregnant HIV-infected Malawian women. We compared peripheral blood leukocyte and lymphocyte subsets between women in the four groups. RESULTS: Parturient HIV-infected and HIV-uninfected women had more neutrophils (each P<.0001), but fewer lymphocytes (P<.0001; P=.0014) than non-pregnant women. Both groups had fewer total T cells (P<.0001; P=.002) and CD8+ T cells (P<.0001; P=.014) than non-pregnant women. HIV-uninfected parturient women had fewer CD4+ and γδ T cells, B and NK cells (each P<.0001) than non-pregnant women. Lymphocyte subset percentages were not affected by pregnancy. CONCLUSION: Malawian women at parturition have an increased total white cell count due to neutrophilia and an HIV-unrelated pan-lymphopenia.
| Type: | Article |
|---|---|
| Title: | Leukocyte counts and lymphocyte subsets in relation to pregnancy and HIV infection in Malawian women |
| Location: | Denmark |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1111/aji.12678 |
| Publisher version: | https://doi.org/10.1111/aji.12678 |
| Language: | English |
| Additional information: | © 2017 The Author. This is an open access article under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
| Keywords: | HIV, leukocytes, lymphocytes, parturition, pregnancy, sepsis, Adolescent, Adult, Aged, Female, HIV, HIV Infections, Humans, Immunity, Cellular, Immunophenotyping, Lymphocyte Count, Lymphocyte Subsets, Malawi, Middle Aged, Parturition, Pregnancy, Pregnancy Complications, Receptors, Antigen, T-Cell, gamma-delta, Sepsis, Young Adult |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10055144 |
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