Chand, M;
Keller, DS;
Mirnezami, R;
Bullock, M;
Bhangu, A;
Moran, B;
Tekkis, PP;
... Berho, M; + view all
(2018)
Novel biomarkers for patient stratification in colorectal cancer: A review of definitions, emerging concepts, and data.
World Journal of Gastrointestinal Oncology
, 10
(7)
pp. 145-158.
10.4251/wjgo.v10.i7.145.
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Abstract
Colorectal cancer (CRC) treatment has become more personalised, incorporating a combination of the individual patient risk assessment, gene testing, and chemotherapy with surgery for optimal care. The improvement of staging with high-resolution imaging has allowed more selective treatments, optimising survival outcomes. The next step is to identify biomarkers that can inform clinicians of expected prognosis and offer the most beneficial treatment, while reducing unnecessary morbidity for the patient. The search for biomarkers in CRC has been of significant interest, with questions remaining on their impact and applicability. The study of biomarkers can be broadly divided into metabolic, molecular, microRNA, epithelial-to-mesenchymal-transition (EMT), and imaging classes. Although numerous molecules have claimed to impact prognosis and treatment, their clinical application has been limited. Furthermore, routine testing of prognostic markers with no demonstrable influence on response to treatment is a questionable practice, as it increases cost and can adversely affect expectations of treatment. In this review we focus on recent developments and emerging biomarkers with potential utility for clinical translation in CRC. We examine and critically appraise novel imaging and molecular-based approaches; evaluate the promising array of microRNAs, analyze metabolic profiles, and highlight key findings for biomarker potential in the EMT pathway.
| Type: | Article |
|---|---|
| Title: | Novel biomarkers for patient stratification in colorectal cancer: A review of definitions, emerging concepts, and data |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.4251/wjgo.v10.i7.145 |
| Publisher version: | https://doi.org/10.4251/wjgo.v10.i7.145 |
| Language: | English |
| Additional information: | © 2018 Baishideng Publishing Group Inc. Articles published by this Open-Access journal are distributed under the terms of the Creative Commons Attribution Non-commercial License, which permits use, distribution, and reproduction in any medium, provided the original work is properly cited, the use is non commercial and is otherwise in compliance with the license. |
| Keywords: | Science & Technology, Life Sciences & Biomedicine, Oncology, Gastroenterology & Hepatology, Biomarker, Colorectal cancer, Epithelial-to-mesenchymal-transition pathway, Molecular biomarker, MicroRNA, Metabolic biomarker, Imaging biomarker, Tumour regression grade, EPITHELIAL-MESENCHYMAL TRANSITION, ADVANCED RECTAL-CANCER, CIRCULATING TUMOR DNA, TOTAL MESORECTAL EXCISION, VEGF-A EXPRESSION, CELL-FREE DNA, BREAST-CANCER, NEOADJUVANT CHEMORADIOTHERAPY, MICRORNA EXPRESSION, NMR-SPECTROSCOPY |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci > Department of Targeted Intervention |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10055328 |
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