Lee, MTW;
Maruani, A;
Baker, JR;
Caddick, S;
Chudasama, V;
(2015)
Next-generation disulfide stapling: reduction and functional re-bridging all in one.
Chemical Science
(1)
pp. 799-802.
10.1039/c5sc02666k.
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Abstract
Herein we present a significant step towards next-generation disulfide stapling reagents. A novel class of reagent has been designed to effect both disulfide reduction and functional re-bridging. The strategy has been applied to great success across various peptides and proteins. Moreover, application to a multi-disulfide system resulted in functional re-bridging without disulfide scrambling.
| Type: | Article |
|---|---|
| Title: | Next-generation disulfide stapling: reduction and functional re-bridging all in one |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1039/c5sc02666k |
| Publisher version: | https://doi.org/10.1039/c5sc02666k |
| Language: | English |
| Additional information: | This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences > Dept of Chemistry |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10056157 |
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