Halverson, HE;
Khilkevich, A;
Mauk, MD;
(2018)
Cerebellar Processing Common to Delay and Trace Eyelid Conditioning.
The Journal of Neuroscience
, 38
(33)
pp. 7221-7236.
10.1523/JNEUROSCI.0430-18.2018.
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Abstract
Results from previous lesion studies have been interpreted as evidence that the cerebellar cortex plays different roles for delay and trace conditioning of eyelid responses. However, the cerebellar cortex is organized by parasagittal stripes of Purkinje cells (PCs) that converge onto common deep nucleus neurons and receive common or related climbing fiber inputs. Based on this organization, we hypothesized that cerebellartasks involvingthe same response system, such as delay andtrace eyelid conditioning, would engagethe same PCs andthat the relationships between PC activity and expression of behavioral responses would be similarfor bothtasks. Totestthese hypotheses, we used tetrode recordings from eyelid PCs in rabbits during expression of delay- and trace-conditioned eyelid responses. Previous recording studies during delay conditioning described a strong relationship between eyelid PC activity andthe kinematics of conditioned eyelid responses. The present results replicate these findings for delay conditioning and show that the same relationship exists during trace eyelid conditioning. Duringtransitionsfrom delaytotrace responding,the relationship between eyelid PCs and behavioral responses was relatively stable. We found that an inverse firing rate model tuned to predict PC activity during one training paradigm could then predict equally well the PC activity during the other training paradigm. These results provide strong evidence that cerebellar cortex processing is similar for delay and trace eyelid conditioning and that the parasagittal organization of the cerebellum, not the conditioning paradigm, dictate which neurons are engaged to produce adaptively timed conditioned responses.
| Type: | Article |
|---|---|
| Title: | Cerebellar Processing Common to Delay and Trace Eyelid Conditioning |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1523/JNEUROSCI.0430-18.2018 |
| Publisher version: | http://dx.doi.org/10.1523/JNEUROSCI.0430-18.2018 |
| Language: | English |
| Additional information: | This version is the version of record. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Science & Technology, Life Sciences & Biomedicine, Neurosciences, Neurosciences & Neurology, cerebellum, eyelid conditioning, modeling, Purkinje cell, tetrode recordings, trace conditioning, NICTITATING-MEMBRANE RESPONSE, MEDIAL AUDITORY THALAMUS, PURKINJE-CELL ACTIVITY, ANTERIOR LOBE, PREVENTS ACQUISITION, INTERPOSITUS NUCLEUS, CORTEX, LESIONS, RABBIT, MICE |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > The Sainsbury Wellcome Centre |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10056661 |
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