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Regulation of endothelial homeostasis, vascular development and angiogenesis by the transcription factor ERG

Shah, AV; Birdsey, GM; Randi, AM; (2016) Regulation of endothelial homeostasis, vascular development and angiogenesis by the transcription factor ERG. Vascular Pharmacology , 86 (C) pp. 3-13. 10.1016/j.vph.2016.05.003. Green open access

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Abstract

Over the last few years, the ETS transcription factor ERG has emerged as a major regulator of endothelial function. Multiple studies have shown that ERG plays a crucial role in promoting angiogenesis and vascular stability during development and after birth. In the mature vasculature ERG also functions to maintain endothelial homeostasis, by transactivating genes involved in key endothelial functions, while repressing expression of pro-inflammatory genes. Its homeostatic role is lineage-specific, since ectopic expression of ERG in non-endothelial tissues such as prostate is detrimental and contributes to oncogenesis. This review summarises the main roles and pathways controlled by ERG in the vascular endothelium, its transcriptional targets and its functional partners and the emerging evidence on the pathways regulating ERG's activity and expression.

Type: Article
Title: Regulation of endothelial homeostasis, vascular development and angiogenesis by the transcription factor ERG
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.vph.2016.05.003
Language: English
Additional information: © 2016 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
Keywords: ETS transcription factors, Gene transcription, Angiogenesis, Vascular development, Endothelial homeostasis
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
URI: https://discovery-pp.ucl.ac.uk/id/eprint/10057363
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