Pierrard, V;
Lebdai, S;
Kleinclauss, F;
Azzouzi, A-R;
Terrier, JE;
Fortier, E;
Joniau, S;
... Ruffion, A; + view all
(2019)
Radical prostatectomy after vascular-targeted photodynamic therapy (VTP) with TOOKAD® : feasibility, early and intermediate results.
The Journal of Urology
, 201
(2)
pp. 315-321.
10.1016/j.juro.2018.08.084.
Preview |
Text
1-s2.0-S0022534718439122-main.pdf - Accepted Version Download (282kB) | Preview |
Abstract
INTRODUCTION: and objectives: vascular-targeted photodynamic therapy with TOOKAD® (VTP) is a new therapeutic option for localized prostate cancer (PCa) management. The objectives are to assess the feasibility of radical prostatectomy (RP) after VTP and describe functional and oncological outcomes. MATERIAL AND METHODS: we retrospectively included 45 patients who underwent salvage RP after VTP for recurrent PCa in 14 surgical centres in Europe between October 2008 and March 2017.Forty-two RP were performed: 16 robot-assisted, 6 by laparoscopy, and 20 by open surgery. Primary endpoints were morbidity and technical difficulties. Secondary endpoints were early and intermediate post-operative functional and oncologic outcomes. RESULTS: Median operative time was 180 (150-223) minutes. Median blood loss was 200 (155-363) millilitres. According to the surgeons, the surgery was "easy" for 29 patients (69%), "difficult" for 13 patients (31%). Nerve sparing was feasible for 14 patients (33%). Five (12%) post-operative complications were found: 2 Claviens I, 2 Clavien II and 1 Clavien IIIB. There was 13 pT3 (31%), 21 (50%) pT2c. Surgical margins were positive for 13 patients (31%). PSA was undetectable at 6-12 months for 37 patients (88%). Nine patients had complementary radiotherapy. Four patients had a last PSA > 0.2 ng/mL with a median follow-up of 23 (12-36) months. At one year, 27 patients (64%) were completely continent (no pads), 10 (24%) had low incontinence (1 pads). Four patients (11 %) recovered potency without treatment, and 23 (64%) with appropriate treatment. CONCLUSION: Salvage RP after VTP treatment was feasible and safe without difficulties for most of the surgeons.
| Type: | Article |
|---|---|
| Title: | Radical prostatectomy after vascular-targeted photodynamic therapy (VTP) with TOOKAD® : feasibility, early and intermediate results |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.juro.2018.08.084 |
| Publisher version: | https://doi.org/10.1016/j.juro.2018.08.084 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Focal therapy, Radical prostatectomy, Vascular-targeted photodynamic therapy, functional outcomes, salvage prostatectomy |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10058046 |
Archive Staff Only
 |
View Item |
