Wong, LH;
Eden, ER;
Futter, CE;
(2018)
Roles for ER : endosome membrane contact sites in ligand-stimulated intraluminal vesicle formation.
[Review].
Biochemical Society Transactions
10.1042/BST20170432.
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Abstract
Multivesicular endosomes/bodies (MVBs) sort membrane proteins between recycling and degradative pathways. Segregation of membrane proteins onto intraluminal vesicles (ILVs) of MVBs removes them from the recycling pathway and facilitates their degradation following fusion of MVBs with lysosomes. Sorting of many cargos onto ILVs depends on the ESCRT (Endosomal Sorting Complex Required for Transport) machinery, although ESCRT-independent mechanisms also exist. In mammalian cells, efficient sorting of ligand-stimulated epidermal growth factor receptors onto ILVs also depends on the tyrosine phosphatase, PTP1B, an ER-localised enzyme that interacts with endosomal targets at membrane contacts between MVBs and the ER. This review focuses on the potential roles played by ER : MVB membrane contact sites in regulating ESCRT-dependent ILV formation.
| Type: | Article |
|---|---|
| Title: | Roles for ER : endosome membrane contact sites in ligand-stimulated intraluminal vesicle formation |
| Location: | England |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1042/BST20170432 |
| Publisher version: | https://doi.org/10.1042/BST20170432 |
| Language: | English |
| Additional information: | © 2018 The Author(s) https://creativecommons.org/licenses/by/4.0/ This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY). |
| Keywords: | EGF receptor, intraluminal vesicle, membrane contact site, membrane trafficking, multivesicular body |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Ophthalmology |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10058075 |
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