van der Laan, SW;
Siemelink, MA;
Haitjema, S;
Asl, HF;
Perisic, L;
Mokry, M;
van Setten, J;
... Pasterkamp, G; + view all
(2018)
Genetic Susceptibility Loci for Cardiovascular Disease and Their Impact on Atherosclerotic Plaques.
Circulation: Genomic and Precision Medicine
, 11
(9)
, Article e002115. 10.1161/CIRCGEN.118.002115.
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Abstract
BACKGROUND: Atherosclerosis is a chronic inflammatory disease in part caused by lipid uptake in the vascular wall, but the exact underlying mechanisms leading to acute myocardial infarction and stroke remain poorly understood. Large consortia identified genetic susceptibility loci that associate with large artery ischemic stroke and coronary artery disease. However, deciphering their underlying mechanisms are challenging. Histological studies identified destabilizing characteristics in human atherosclerotic plaques that associate with clinical outcome. To what extent established susceptibility loci for large artery ischemic stroke and coronary artery disease relate to plaque characteristics is thus far unknown but may point to novel mechanisms. METHODS: We studied the associations of 61 established cardiovascular risk loci with 7 histological plaque characteristics assessed in 1443 carotid plaque specimens from the Athero-Express Biobank Study. We also assessed if the genotyped cardiovascular risk loci impact the tissue-specific gene expression in 2 independent biobanks, Biobank of Karolinska Endarterectomy and Stockholm Atherosclerosis Gene Expression. RESULTS: A total of 21 established risk variants (out of 61) nominally associated to a plaque characteristic. One variant (rs12539895, risk allele A) at 7q22 associated to a reduction of intraplaque fat, P=5.09×10−6 after correction for multiple testing. We further characterized this 7q22 Locus and show tissue-specific effects of rs12539895 on HBP1 expression in plaques and COG5 expression in whole blood and provide data from public resources showing an association with decreased LDL (low-density lipoprotein) and increase HDL (high-density lipoprotein) in the blood. CONCLUSIONS: Our study supports the view that cardiovascular susceptibility loci may exert their effect by influencing the atherosclerotic plaque characteristics.
| Type: | Article |
|---|---|
| Title: | Genetic Susceptibility Loci for Cardiovascular Disease and Their Impact on Atherosclerotic Plaques |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1161/CIRCGEN.118.002115 |
| Publisher version: | https://doi.org/10.1161/CIRCGEN.118.002115 |
| Language: | English |
| Additional information: | This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
| Keywords: | Science & Technology, Life Sciences & Biomedicine, Cardiac & Cardiovascular Systems, Genetics & Heredity, Cardiovascular System & Cardiology, atherosclerosis, cardiovascular disease, coronary artery disease, genetic loci, plaque, atherosclerotic, quantitative trait loci, stroke, GENOME-WIDE ASSOCIATION, CORONARY-ARTERY-DISEASE, GOLGI COG COMPLEX, ISCHEMIC-STROKE, COMMON VARIANTS, TRANSCRIPTIONAL REPRESSOR, EXPRESSION, HBP1, METAANALYSIS, PROTEIN |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Health Informatics |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10058088 |
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