Yang, Y;
Li, W;
Yu, D-G;
Wang, G;
Williams, GR;
Zhang, Z;
(2019)
Tunable drug release from nanofibers coated with blank cellulose acetate layers fabricated using tri-axial electrospinning.
Carbohydrate Polymers
, 203
pp. 228-237.
10.1016/j.carbpol.2018.09.061.
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Abstract
In this study, novel core-shell nanostructures were fabricated through a modified triaxial electrospinning process. These comprised a drug-protein nanocomposite coated with a thin cellulose acetate (CA) shell. They were generated through the simultaneous treatment of an outer solvent, an unelectrospinnable middle fluid, and an electrospinnable core solution in triaxial electrospinning. SEM and TEM results revealed that the core-shell nanofibers had linear and cylindrical morphologies with a diameter from 0.66 to 0.87 μm, and distinct core-shell structures with a shell thickness from 1.8 to 11.6 nm. The presence of a CA coating eliminated the initial burst release of ibuprofen seen from a monolithic drug-protein composite, and allowed us to precisely manipulate the drug release (for a 90% percentage) over a time period from 23.5 to 43.9 h in a tunable manner. Mathematical relationships between the processing conditions, the nanostructures produced, and their functional performance were elucidated.
| Type: | Article |
|---|---|
| Title: | Tunable drug release from nanofibers coated with blank cellulose acetate layers fabricated using tri-axial electrospinning |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.carbpol.2018.09.061 |
| Publisher version: | https://doi.org/10.1016/j.carbpol.2018.09.061 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Modified triaxial electrospinning, Detachable tri-layer spinneret, Cellulose acetate nanocoating, Structural nanohybrids, Linear drug release, Process–nanostructure–performance relationship |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy > Pharmaceutics |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10058381 |
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