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Cooperation of dual modes of cell motility promotes epithelial stress relaxation to accelerate wound healing

Staddon, MF; Bi, D; Tabatabai, AP; Ajeti, V; Murrell, MP; Banerjee, S; (2018) Cooperation of dual modes of cell motility promotes epithelial stress relaxation to accelerate wound healing. PLoS Computational Biology , 14 (10) , Article e1006502. 10.1371/journal.pcbi.1006502. Green open access

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Abstract

Collective cell migration in cohesive units is vital for tissue morphogenesis, wound repair, and immune response. While the fundamental driving forces for collective cell motion stem from contractile and protrusive activities of individual cells, it remains unknown how their balance is optimized to maintain tissue cohesiveness and the fluidity for motion. Here we present a cell-based computational model for collective cell migration during wound healing that incorporates mechanochemical coupling of cell motion and adhesion kinetics with stochastic transformation of active motility forces. We show that a balance of protrusive motility and actomyosin contractility is optimized for accelerating the rate of wound repair, which is robust to variations in cell and substrate mechanical properties. This balance underlies rapid collective cell motion during wound healing, resulting from a tradeoff between tension mediated collective cell guidance and active stress relaxation in the tissue.

Type: Article
Title: Cooperation of dual modes of cell motility promotes epithelial stress relaxation to accelerate wound healing
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1371/journal.pcbi.1006502
Publisher version: http://dx.doi.org/10.1371/journal.pcbi.1006502
Language: English
Additional information: © 2018 Staddon et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
UCL classification: UCL
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences
URI: https://discovery-pp.ucl.ac.uk/id/eprint/10058785
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