Yánez, DC;
Sahni, H;
Ross, S;
Solanki, A;
Lau, C-I;
Papaioannou, E;
Barbarulo, A;
... Crompton, T; + view all
(2019)
IFITM proteins drive type 2 T helper cell differentiation and exacerbate allergic airway inflammation.
European Journal of Immunology
, 49
(1)
pp. 66-78.
10.1002/eji.201847692.
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Abstract
The interferon-inducible transmembrane (Ifitm/Fragilis) genes encode homologous proteins that are induced by IFNs. Here we show that IFITM proteins regulate murine CD4 T-helper cell differentiation. Ifitm2 and Ifitm3 are expressed in wild-type (WT) CD4 T-cells. On activation, Ifitm3 was downregulated and Ifitm2 was upregulated. Resting Ifitm-family-deficient CD4 T-cells had higher expression of Th1-associated genes than WT and purified naive Ifitm-family-deficient CD4 T-cells differentiated more efficiently to Th1, whereas Th2-differentiation was inhibited. Ifitm-family-deficient mice, but not Ifitm3-deficient mice, were less susceptible than WT to induction of allergic airways disease, with a weaker Th2 response and less severe disease and lower Il4 but higher Ifng expression and IL-27 secretion. Thus, the Ifitm-family is important in adaptive immunity, influencing Th1/Th2-polarization and Th2-immunopathology.
| Type: | Article |
|---|---|
| Title: | IFITM proteins drive type 2 T helper cell differentiation and exacerbate allergic airway inflammation |
| Location: | Germany |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1002/eji.201847692 |
| Publisher version: | http://doi.org/10.1002/eji.201847692 |
| Language: | English |
| Additional information: | © 2018 The Authors. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0/ |
| Keywords: | Allergic airway disease, IFN-g, Interferon-inducible transmembrane (IFITM) protein, T helper 1 (Th1), T helper 2 (Th2) |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Infection, Immunity and Inflammation Dept |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10060403 |
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