Chen, MB;
Kamm, RD;
Moeendarbary, E;
(2018)
Engineered Models of Metastasis with Application to Study Cancer Biomechanics.
In: Dong, C and Zahir, N and Konstantopoulos, K, (eds.)
Biomechanics in Oncology.
(pp. 189-207).
Springer Nature: Cham, Switzerland.
Preview |
Text
Moeendarbary_Engineered Models of Metastasis with Application to Study Cancer Biomechanics_AAM.pdf - Accepted Version Download (774kB) | Preview |
Abstract
Three-dimensional complex biomechanical interactions occur from the initial steps of tumor formation to the later phases of cancer metastasis. Conventional monolayer cultures cannot recapitulate the complex microenvironment and chemical and mechanical cues that tumor cells experience during their metastatic journey, nor the complexity of their interactions with other, noncancerous cells. As alternative approaches, various engineered models have been developed to recapitulate specific features of each step of metastasis with tunable microenvironments to test a variety of mechanistic hypotheses. Here the main recent advances in the technologies that provide deeper insight into the process of cancer dissemination are discussed, with an emphasis on three-dimensional and mechanical factors as well as interactions between multiple cell types.
| Type: | Book chapter |
|---|---|
| Title: | Engineered Models of Metastasis with Application to Study Cancer Biomechanics |
| ISBN-13: | 978-3-319-95293-2 |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1007/978-3-319-95294-9_10 |
| Publisher version: | https://doi.org/10.1007/978-3-319-95294-9_10 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Cancer metastasis, Mechanobiology, Tumorigenesis, Intravasation, Extravasation, Cell migration, Vascularization, Cancer models, Microfluidics, Tumor spheroids |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Mechanical Engineering |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10061421 |
Archive Staff Only
 |
View Item |
