Pesenacker, AM;
Cook, L;
Levings, MK;
(2016)
The role of FOXP3 in autoimmunity.
Current Opinion in Immunology
, 43
pp. 16-23.
10.1016/j.coi.2016.07.004.
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Abstract
FOXP3 controls the development and function of T regulatory cells (Tregs). Autoimmunity is linked to changes in FOXP3 activity that can occur at multiple levels and lead to Treg dysfunction. For example, changes in IL-2 signaling, FOXP3 transcription and/or post-translational modifications can all contribute to loss of self-tolerance. As additional pathways of FOXP3 regulation are elucidated, new therapeutic approaches to increase Treg activity either by cell therapy or pharmacological intervention are being tested. Early success from pioneering studies of Treg-based therapy in transplantation has promoted the undertaking of similar studies in autoimmunity, with emerging evidence for the effectiveness of these approaches, particularly in the context of type 1 diabetes.
| Type: | Article |
|---|---|
| Title: | The role of FOXP3 in autoimmunity |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.coi.2016.07.004 |
| Publisher version: | https://doi.org/10.1016/j.coi.2016.07.004 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Infection and Immunity |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10063594 |
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