UCL Discovery Stage
UCL home » Library Services » Electronic resources » UCL Discovery Stage

Entropy production rate is maximized in non-contractile actomyosin

Seara, DS; Yadav, V; Linsmeier, I; Tabatabai, AP; Oakes, PW; Tabei, SMA; Banerjee, S; (2018) Entropy production rate is maximized in non-contractile actomyosin. Nature Communications , 9 , Article 4948. 10.1038/s41467-018-07413-5. Green open access

[thumbnail of Banerjee_s41467-018-07413-5.pdf]
Preview
Text
Banerjee_s41467-018-07413-5.pdf - Published Version

Download (2MB) | Preview

Abstract

The actin cytoskeleton is an active semi-flexible polymer network whose non-equilibrium properties coordinate both stable and contractile behaviors to maintain or change cell shape. While myosin motors drive the actin cytoskeleton out-of-equilibrium, the role of myosin-driven active stresses in the accumulation and dissipation of mechanical energy is unclear. To investigate this, we synthesize an actomyosin material in vitro whose active stress content can tune the network from stable to contractile. Each increment in activity determines a characteristic spectrum of actin filament fluctuations which is used to calculate the total mechanical work and the production of entropy in the material. We find that the balance of work and entropy does not increase monotonically and the entropy production rate is maximized in the non-contractile, stable state of actomyosin. Our study provides evidence that the origins of entropy production and activity-dependent dissipation relate to disorder in the molecular interactions between actin and myosin.

Type: Article
Title: Entropy production rate is maximized in non-contractile actomyosin
Open access status: An open access version is available from UCL Discovery
DOI: 10.1038/s41467-018-07413-5
Publisher version: https://doi.org/10.1038/s41467-018-07413-5
Language: English
Additional information: This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
UCL classification: UCL
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences
URI: https://discovery-pp.ucl.ac.uk/id/eprint/10063730
Downloads since deposit
3,456Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item