Manoharan, A;
Rayner, PJ;
Iali, W;
Burns, MJ;
Perry, VH;
Duckett, SB;
(2018)
Achieving Biocompatible SABRE: An invitro Cytotoxicity Study.
ChemMedChem
, 13
(4)
pp. 352-359.
10.1002/cmdc.201700725.
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Abstract
Production of a biocompatible hyperpolarized bolus for signal amplification by reversible exchange (SABRE) could open the door to simple clinical diagnosis via magnetic resonance imaging. Essential to successful progression to preclinical/clinical applications is the determination of the toxicology profile of the SABRE reaction mixture. Herein, we exemplify the cytotoxicity of the SABRE approach using in vitro cell assays. We conclude that the main cause of the observed toxicity is due to the SABRE catalyst. We therefore illustrate two catalyst removal methods: one involving deactivation and ion‐exchange chromatography, and the second using biphasic catalysis. These routes produce a bolus suitable for future in vivo study.
| Type: | Article |
|---|---|
| Title: | Achieving Biocompatible SABRE: An invitro Cytotoxicity Study |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1002/cmdc.201700725 |
| Publisher version: | http://doi.org/10.1002/cmdc.201700725 |
| Language: | English |
| Additional information: | Copyright © 2018 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
| Keywords: | biocompatibility, biphasic catalysis, cytotoxicity, hyperpolarization, SABRE |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UK Dementia Research Institute HQ |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10064011 |
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