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History of thyroid disease and survival of ovarian cancer patients: results from the Ovarian Cancer Association Consortium, a brief report

Minlikeeva, AN; Freudenheim, JL; Cannioto, RA; Eng, KH; Szender, JB; Mayor, P; Etter, JL; ... Moysich, KB; + view all (2017) History of thyroid disease and survival of ovarian cancer patients: results from the Ovarian Cancer Association Consortium, a brief report. British Journal of Cancer , 117 (7) pp. 1063-1069. 10.1038/bjc.2017.267. Green open access

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Abstract

BACKGROUND: Findings from in vitro studies suggest that increased exposure to thyroid hormones can influence progression of ovarian tumours. However, epidemiologic evidence on this topic is limited. METHODS: We pooled data from 11 studies from the Ovarian Cancer Association Consortium. Using multivariate Cox proportional hazards models, we estimated associations between hyper- and hypothyroidism and medications prescribed for these conditions with 5-year all-cause survival among women diagnosed with invasive ovarian cancer. RESULTS: Overall, there was a nonsignificant association with history of hyperthyroidism (n=160 cases) and mortality (HR=1.22; 95% CI=0.97-1.53). Furthermore, diagnosis of hyperthyroidism within the 5 years before ovarian cancer diagnosis was associated with an increased risk of death (HR=1.94; 95% CI=1.19-3.18). A more modest association was observed with history of hypothyroidism (n=624 cases) and mortality (HR=1.16; 95% CI=1.03-1.31). Neither duration of hypothyroidism nor use of thyroid medications was associated with survival. CONCLUSIONS: In this large study of women with ovarian cancer, we found that recent history of hyperthyroidism and overall history of hypothyroidism were associated with worse 5-year survival.

Type: Article
Title: History of thyroid disease and survival of ovarian cancer patients: results from the Ovarian Cancer Association Consortium, a brief report
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1038/bjc.2017.267
Publisher version: http://doi.org/10.1038/bjc.2017.267
Language: English
Additional information: This work is published under the standard license to publish agreement. After 12 months the work will become freely available and the license terms will switch to a Creative Commons AttributionNonCommercial-Share Alike 4.0 Unported License.
Keywords: Aged, Female, Humans, Hyperthyroidism, Hypothyroidism, Middle Aged, Ovarian Neoplasms, Proportional Hazards Models, Survival Rate, Time Factors
URI: https://discovery-pp.ucl.ac.uk/id/eprint/10064021
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