Zaiss, M;
Herz, K;
Deshmane, A;
Kim, M;
Golay, X;
Lindig, T;
Bender, B;
... Scheffler, K; + view all
(2019)
Possible artifacts in dynamic CEST MRI due to motion and field alterations.
Journal of Magnetic Resonance
, 298
pp. 16-22.
10.1016/j.jmr.2018.11.002.
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Abstract
PURPOSE: Dynamic CEST studies such as dynamic glucose enhanced imaging, have gained a lot of attention recently. The expected CEST effects after injection are rather small in tissue especially at clinical field strengths (0.5-2%). Small movements during the dynamic CEST measurement together with a subtraction-based evaluation can lead to pseudo CEST effects of the same order of magnitude. These artifacts are studied herein. METHODS: A brain tumor patient 3D-CEST baseline scan without glucose injection performed at 3 T is used to generate a virtual dynamic measurement introducing different kinds of simulated motion and B0 shifts. RESULTS: Minor motion (0.6 mm translations) and B0 artifacts (7 Hz shift) can lead to pseudo effects in the order of 1% in dynamic CEST imaging. Especially around tissue interfaces such as CSF borders or tumor affected areas, the pseudo effect patterns are non-intuitive and can be mistaken as dynamic agent uptake. CONCLUSION: Correction or mitigation for small motions is crucial for dynamic CEST imaging, especially in subjects with lesions. Concomitant B0 alterations can as well induce pseudo CEST effects at 3 T.
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