Oppedal, K;
Ferreira, D;
Cavallin, L;
Lemstra, AW;
Ten Kate, M;
Padovani, A;
Rektorova, I;
... Alzheimer's Disease Neuroimaging Initiative, .; + view all
(2019)
A signature pattern of cortical atrophy in dementia with Lewy bodies: A study on 333 patients from the European DLB consortium.
Alzheimer's & Dementia
, 15
(3)
pp. 400-409.
10.1016/j.jalz.2018.09.011.
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Abstract
INTRODUCTION: We explored regional brain atrophy patterns and their clinical correlates in dementia with Lewy bodies (DLB). METHODS: In this multicentre study, we included a total of 333 patients with DLB, 352 patients with Alzheimer's disease (AD), and 233 normal controls and used medial temporal lobe atrophy, posterior atrophy, and frontal atrophy (GCA-F) visual rating scales. Patients were classified according to four atrophy patterns. RESULTS: Patients with DLB had higher scores on all the three atrophy scales than normal controls but had less medial temporal lobe atrophy than those with AD (all P values < .001). A signature hippocampal-sparing pattern of regional atrophy was observed in DLB. The magnetic resonance imaging measures showed 65% ability to discriminate between DLB and AD and marginally contributed to the discrimination over and above the core clinical features. DISCUSSION: The most common pattern of atrophy of DLB was hippocampal-sparing. Future studies should explore whether comorbid AD pathology underlies the atrophy patterns seen in DLB.
| Type: | Article |
|---|---|
| Title: | A signature pattern of cortical atrophy in dementia with Lewy bodies: A study on 333 patients from the European DLB consortium |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.jalz.2018.09.011 |
| Publisher version: | https://doi.org/10.1016/j.jalz.2018.09.011 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Dementia, Alzheimer's disease, Dementia with Lewy bodies, Medial temporal atrophy, Posterior atrophy frontal atrophy, Typical Alzheimer's disease atrophy pattern, Limbic-predominant atrophy pattern, Hippocampal spearing atrophy pattern, Minimal-atrophy pattern, Differential diagnosis, Magnetic resonance imaging, Neuroimaging |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Division of Psychiatry |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10064437 |
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