Irtan, S;
Messahel, B;
Moroz, V;
Taylor, RE;
Grundy, R;
Kelsey, A;
Vujanic, G;
(2019)
Outcomes of non-anaplastic stage III and ‘inoperable’ Wilms tumour treated in the UKW3 trial.
Radiotherapy and Oncology
, 131
pp. 1-7.
10.1016/j.radonc.2018.10.026.
Preview |
Text (Article)
Irtan_Manuscript Green Journal final submitted.pdf - Accepted Version Download (132kB) | Preview |
Preview |
Text (Tables)
Irtan_Tables.pdf - Accepted Version Download (93kB) | Preview |
Preview |
Text (Figures)
Irtan_Figures.pdf - Accepted Version Download (247kB) | Preview |
Abstract
BACKGROUND AND PURPOSE: To describe the outcome of patients with stage III Wilms tumours (WT) treated in the UKW3 trial. MATERIAL AND METHODS: Patients with a pathologically confirmed stage III non-anaplastic WT at nephrectomy (Group A) or with an ‘inoperable’ tumour at diagnosis managed by biopsy and pre-operative chemotherapy (Actinomycin D-Vincristine-Doxorubicin) but stage I or II at subsequent nephrectomy (Group B) were included. RESULTS: The 4-year overall (OS)/event free survival (EFS) for Group A (n = 117) patients was 90%(95%CI:83–94)/81%(CI:73–87) and for Group B (n = 32) 94%(CI:77–98)/88%(CI:70–95). The 4-year OS/EFS of patients with pathological stage III WT according to whether they received flank/abdominal radiotherapy (95 patients) or not (37 patients, 22 from UKW3 pooled with 17 patients from UKW2) were 91%(CI:83–95)/82%(CI:73–89), and 84%(CI:67–92)/78%(CI:61–89), respectively. The 4-year OS/EFS for patients having one reason to be stage III versus two or three was 92%(CI:84–96)/83%(CI:73–90) and 85%(CI:70–93)/78%(CI:61–88), respectively. CONCLUSION: Our findings question the inclusion of biopsy or pre-operative chemotherapy as sole criterion for assigning a tumour stage III. Selected patients with pathological stage III WT can survive without radiotherapy. Whilst cautious interpretation is needed due to the post hoc nature of these analyses, further biological studies may better characterise those who could benefit from reduced therapy.
| Type: | Article |
|---|---|
| Title: | Outcomes of non-anaplastic stage III and ‘inoperable’ Wilms tumour treated in the UKW3 trial |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.radonc.2018.10.026 |
| Publisher version: | https://doi.org/10.1016/j.radonc.2018.10.026 |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Developmental Biology and Cancer Dept |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10065785 |
Archive Staff Only
 |
View Item |
