Asquith, C;
Laitinen, T;
Konstantinova, L;
Tizzard, G;
Poso, A;
Rakitin, O;
Hofmann-Lehmann, R;
(2019)
Investigation of the Pentathiepin Functionality as an Inhibitor of Feline Immunodeficiency Virus (FIV) via a Potential Zinc Ejection Mechanism, as a Model for HIV Infection.
ChemMedChem
, 14
(4)
pp. 454-461.
10.1002/cmdc.201800718.
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Abstract
A small diverse library of pentathiepin derivatives were prepared to evaluate their efficacy against the nucleocapsid protein function of the Feline Immunodeficiency Virus (FIV) as a model for HIV, using an in‐vitro cell culture approach. This approach led to the development of nanomolar active compounds with low toxicity.
| Type: | Article |
|---|---|
| Title: | Investigation of the Pentathiepin Functionality as an Inhibitor of Feline Immunodeficiency Virus (FIV) via a Potential Zinc Ejection Mechanism, as a Model for HIV Infection |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1002/cmdc.201800718 |
| Publisher version: | https://doi.org/10.1002/cmdc.201800718 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Pentathiepin, Feline Immunodeficiency Virus (FIV), Human Immunodeficiency Virus (HIV), Nucleocapsid Protein, Zinc Ejection |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy > Pharma and Bio Chemistry |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10066114 |
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