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Loss of miR-210 leads to progressive retinal degeneration in Drosophila melanogaster

Partridge, L; (2019) Loss of miR-210 leads to progressive retinal degeneration in Drosophila melanogaster. Life Sciences Alliance , 2 (1) , Article e201800149. 10.26508/lsa.201800149. Green open access

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Abstract

miRNAs are small, non-coding RNAs that regulate gene expression post-transcriptionally. We used small RNA sequencing to identify tissue-specific miRNAs in the adult brain, thorax, gut, and fat body of Drosophila melanogaster. One of the most brain-specific miRNAs that we identified was miR-210, an evolutionarily highly conserved miRNA implicated in the regulation of hypoxia in mammals. In Drosophila, we show that miR-210 is specifically expressed in sensory organs, including photoreceptors. miR-210 knockout mutants are not sensitive toward hypoxia but show progressive degradation of photoreceptor cells, accompanied by decreased photoreceptor potential, demonstrating an important function of miR-210 in photoreceptor maintenance and survival.

Type: Article
Title: Loss of miR-210 leads to progressive retinal degeneration in Drosophila melanogaster
Open access status: An open access version is available from UCL Discovery
DOI: 10.26508/lsa.201800149
Publisher version: http://doi.org/10.26508/lsa.201800149
Language: English
Additional information: This article is available under a Creative Commons License (Attribution 4.0 International, as described at https://creativecommons.org/ licenses/by/4.0/).
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Genetics, Evolution and Environment
URI: https://discovery-pp.ucl.ac.uk/id/eprint/10066537
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