Brogueira Rodrigues, FA;
Byrne, L;
De Vita, E;
Johnson, E;
Hobbs, N;
Thornton, J;
Scahill, R;
(2019)
Cerebrospinal fluid flow dynamics in Huntington's disease evaluated by phase contrast MRI.
European Journal of Neuroscience
10.1111/ejn.14356.
(In press).
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Brogueira Rodrigues VoR 2019 01 Eur J Neurosci Cerebrospinal fluid flow dynamics in Huntington's disease evaluated by phase contrast MRI.pdf - Published Version Download (375kB) | Preview |
Abstract
Multiple targeted therapeutics for Huntington’s disease are now in clinical trials, including intrathecally-delivered compounds. Previous research suggests CSF dynamics may be altered in Huntington’s disease, which could be of paramount relevance to intrathecal drug delivery to the brain. To test this hypothesis we conducted a prospective cross-sectional study comparing people with early stage Huntington’s disease with age- and gender-matched healthy controls. CSF peak velocity, mean velocity and mean flow at the level of the cerebral aqueduct, and sub-arachnoid space in the upper and lower spine, were quantified using phase contrast MRI. We calculated Spearman’s rank correlations, and tested inter-group differences with Wilcoxon rank-sum test. Ten people with early Huntington’s disease, and 10 controls were included. None of the quantified measures was associated with potential modifiers of CSF dynamics (demographics, osmolality, and brain volumes), or by know modifiers of Huntington’s disease (age and CAG-repeat); and no significant differences were found between the two studied groups. While external validation is required, the attained results are sufficient to conclude tentatively that a clinically-relevant alteration of CSF dynamics – i.e. one that would justify dose-adjustments of intrathecal drugs – is unlikely to exist in Huntington’s disease.
| Type: | Article |
|---|---|
| Title: | Cerebrospinal fluid flow dynamics in Huntington's disease evaluated by phase contrast MRI |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1111/ejn.14356 |
| Publisher version: | https://doi.org/10.1111/ejn.14356 |
| Language: | English |
| Additional information: | This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
| Keywords: | Huntington disease; Cerebrospinal Fluid; Magnetic Resonance Imaging; Humans |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Neurodegenerative Diseases |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10066656 |
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