Attrill, H;
Gaudet, P;
Huntley, RP;
Lovering, RC;
Engel, SR;
Poux, S;
Van Auken, KM;
... Gene Ontology Consortium; + view all
(2019)
Annotation of gene product function from high-throughput studies using the Gene Ontology.
Database
, 2019
, Article baz007. 10.1093/database/baz007.
(In press).
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Abstract
High-throughput studies constitute an essential and valued source of information for researchers. However, high-throughput experimental workflows are often complex, with multiple data sets that may contain large numbers of false positives. The representation of high-throughput data in the Gene Ontology (GO) therefore presents a challenging annotation problem, when the overarching goal of GO curation is to provide the most precise view of a gene's role in biology. To address this, representatives from annotation teams within the GO Consortium reviewed high-throughput data annotation practices. We present an annotation framework for high-throughput studies that will facilitate good standards in GO curation and, through the use of new high-throughput evidence codes, increase the visibility of these annotations to the research community.
| Type: | Article |
|---|---|
| Title: | Annotation of gene product function from high-throughput studies using the Gene Ontology |
| Location: | England |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1093/database/baz007 |
| Publisher version: | http://doi.org/10.1093/database/baz007 |
| Language: | English |
| Additional information: | Copyright © The Author(s) 2019. Published by Oxford University Press. Page 1 of 8 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science > Pre-clinical and Fundamental Science |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10067725 |
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