Printzlau, F;
Wolstencroft, J;
Skuse, DH;
(2017)
Cognitive, Behavioral, and Neural Consequences of Sex Chromosome Aneuploidy.
Journal of Neuroscience Research
, 95
(1-2)
pp. 311-319.
10.1002/jnr.23951.
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Abstract
The X chromosome has played a critical role in the development of sexually selected characteristics for over 300 million years, and during that time it has accumulated a disproportionate number of genes concerned with mental functions. There are relatively specific effects of X‐linked genes on social cognition, language, emotional regulation, visuospatial, and numerical skills. Many human X‐linked genes outside the X–Y pairing pseudoautosomal regions escape X‐inactivation. Dosage differences in the expression of such genes (which constitute at least 15% of the total) are likely to play an important role in male–female neural differentiation, and in cognitive deficits and behavioral characteristics, particularly in the realm of social communication, that are associated with sex chromosome aneuploidies.
| Type: | Article |
|---|---|
| Title: | Cognitive, Behavioral, and Neural Consequences of Sex Chromosome Aneuploidy |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1002/jnr.23951 |
| Publisher version: | https://doi.org/10.1002/jnr.23951 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Science & Technology, Life Sciences & Biomedicine, Neurosciences, Neurosciences & Neurology, X chromosome, Y chromosome, autism, ADHD, language, PERVASIVE DEVELOPMENTAL DISORDERS, OF-THE-LITERATURE, XXY KLINEFELTER-SYNDROME, ESCAPE X-INACTIVATION, TURNER-SYNDROME, HUMAN BRAIN, DOSAGE COMPENSATION, XYY SYNDROME, GENERAL INTELLIGENCE, LINKED GENES |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Population, Policy and Practice Dept |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10068199 |
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