Marakalala, MJ;
Martinez, FO;
Pluddemann, A;
Gordon, S;
(2018)
Macrophage Heterogeneity in the Immunopathogenesis of Tuberculosis.
[Review].
Frontiers in Microbiology
, 9
, Article 1028. 10.3389/fmicb.2018.01028.
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Abstract
Macrophages play a central role in tuberculosis, as the site of primary infection, inducers and effectors of inflammation, innate and adaptive immunity, as well as mediators of tissue destruction and repair. Early descriptions by pathologists have emphasized their morphological heterogeneity in granulomas, followed by delineation of T lymphocyte-dependent activation of anti-mycobacterial resistance. More recently, powerful genetic and molecular tools have become available to describe macrophage cellular properties and their role in host-pathogen interactions. In this review we discuss aspects of macrophage heterogeneity relevant to the pathogenesis of tuberculosis and, conversely, lessons that can be learnt from mycobacterial infection, with regard to the immunobiological functions of macrophages in homeostasis and disease.
| Type: | Article |
|---|---|
| Title: | Macrophage Heterogeneity in the Immunopathogenesis of Tuberculosis |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.3389/fmicb.2018.01028 |
| Publisher version: | http://doi.org/10.3389/fmicb.2018.01028 |
| Language: | English |
| Additional information: | Copyright © 2018 Marakalala, Martinez, Plüddemann and Gordon. This is an openaccess article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
| Keywords: | macrophage, immunopathogenesis, tuberculosis, pulmonary, macrophage heterogeneity4, Mycobacterium tuberculosis |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Infection and Immunity |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10069994 |
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